In this session, our four esteemed speakers will both look back over the many contributions from the pharmacoepidemiological society to the handling of the COVID-19 pandemic, as well as outline both learnings and likely challenges that lies ahead. Specifically, we will discuss the value of coordinated global collaborations in addressing urgent safety issues, what methodological insights we should take from these recent years, what regulators have learned and will expect from the pharmacoepidemiological society in the future, and what areas of the pandemic that will likely provide the study questions of the future.