This issue of Value in Health features an ISPOR Good Research Practices Task Force Report that makes recommendations for estimating health-state utility (HSU) for economic models in clinical studies, accompanied by an editorial by Professor Karen Kuntz. The Task Force Report states the consensus position of the ISPOR Task Force on Good Practices for Outcomes Research–Measurement of Health-State Utility Values for Economic Models in Clinical Studies. The report was developed under the ISPOR Vision 2020 initiative, which identified “Estimating health-state utilities for cost-effectiveness analysis” as one of the top two priorities for the development of good research practices guidance, as no such guidance existed.